The Unseen Impact of an Observable Disease: Association of Dihydrotestosterone Levels and Psychosocial Impact in Androgenetic Alopecia: An Analytical Cross-Sectional Study

December 2025 in “ IP Indian Journal of Clinical and Experimental Dermatology ”

Madhur Gupta, Palak Dinesh Hemrajani

dihydrotestosterone androgenetic alopecia psychosocial impact depression PHQ-8 PROMIS T-score DHT AGA

TLDR Androgenetic alopecia in males is linked to significant psychological distress, highlighting the need for both mental and dermatological care.

This study of 48 males with androgenetic alopecia (AGA) reveals a significant psychological burden, with over half experiencing moderate to severe depression. The mean PHQ-8 score was 11.35, and the average PROMIS T-score was 29.95, indicating psychosocial distress. Elevated serum dihydrotestosterone (DHT) levels, averaging 46.59 ng/dL, were observed, with a trend suggesting that higher DHT levels may correlate with more severe depressive symptoms and lower psychosocial functioning, though not statistically significant. The findings underscore the importance of a comprehensive management approach for AGA that includes psychological evaluation and support alongside dermatological treatment.

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