Diagnosis And Treatment Of Cushing's Syndrome In Dogs

January 1983 in “ Journal of the Japan Veterinary Medical Association ”

Yukio Tamura

Cushing syndrome alopecia hydrocortisone ACTH-dependent adrenal hyperplasia adrenalectomy o, p'-DDD Cushing's disease hair loss cortisol ACTH surgery Mitotane

TLDR Daily treatment eventually improved the dog's symptoms.

A toy poodle spontaneously developed Cushing syndrome, showing symptoms like systemic alopecia and increased abdominal girth. Initial tests indicated leukocytosis, hyperglycemia, and high plasma hydrocortisone levels. The dog was diagnosed with ACTH-dependent bilateral adrenal hyperplasia. An initial unilateral adrenalectomy did not alleviate symptoms, so o, p'-DDD was administered. After six weekly doses failed to reduce hydrocortisone levels, daily administration for 10 days led to anorexia and oliguria, prompting treatment suspension. Two weeks later, hair growth resumed, and hematological symptoms improved.

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