The Diagnostic Algorithm in Pre-Invasive Cervical Lesions

    Mihai-George Loghin, Oana Balalau, Nicolae Bacalbașa, Adriana Vasilache, Octavian Olaru, Andrei Vasilache, Anca Daniela Stănescu
    TLDR Early screening and HPV vaccination reduce cervical cancer risk.
    The paper reviewed the diagnostic algorithm for pre-invasive cervical lesions, emphasizing early detection through regular Pap smears and HPV genotyping to reduce cervical cancer incidence. It noted that HPV infection was a primary cause of most intraepithelial lesions, with other factors like immunosuppression and multiparity also contributing. The document highlighted the transient nature of HPV and the potential for spontaneous regression of lesions, while stressing the importance of monitoring and potential surgical intervention for lesions that may progress to invasive cancer. HPV vaccination was recommended to lower recurrence rates in CIN2 patients, although it had no therapeutic effect on existing lesions. Early diagnosis and timely treatment were supported by national health programs.
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