The Potential of Dihydroquercetin and Other Active Substances in Cosmetic Products for Regulating Hair Follicle Activity in the Periorbital Region: A Review

April 2026 in “ Ekologiya Cheloveka (Human Ecology) ”

Alina V. Mindiyarova, Kirill O. Sinyakov, Evgeniy S. Burenkov, Andrej M. Grjibovski

dihydroquercetin adenosine kopyrrol cyclodextrin encapsulation hair follicle activity eyelash growth eyebrow growth signaling pathways growth factors

TLDR Dihydroquercetin and other substances may help eyelash and eyebrow growth, but more research is needed.

This review examines the potential of dihydroquercetin and other active substances in cosmetic products for enhancing hair follicle activity in the periorbital region. Dihydroquercetin's antioxidant properties may improve hair follicle health, but its clinical efficacy in promoting eyelash and eyebrow growth is unproven due to limited solubility and bioavailability. Methods like using cyclodextrins could enhance these properties. Combining dihydroquercetin with substances like adenosine and minoxidil might boost effectiveness in stimulating hair growth. Minoxidil is noted for its effectiveness in treating alopecia, with significant improvements in hair diameter and density. The review suggests that combining these substances could lead to effective cosmetic products, though more research is needed to confirm these benefits.

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