Diverse Role of OX40 on T Cells as a Therapeutic Target for Skin Diseases

February 2023 in “ Journal of Investigative Dermatology ”

Hisato Iriki, Hayato Takahashi, Masayuki Amagai

TLDR OX40-targeted therapies may help treat skin diseases by reducing inflammation and balancing immune responses.

The review discussed the role of OX40, a costimulatory molecule on T cells, as a therapeutic target for skin diseases such as atopic dermatitis, psoriasis, and alopecia areata. OX40 played a crucial role in T-cell survival and memory differentiation, with the OX40/OX40L interaction being significant in autoimmune diseases like alopecia areata. Clinical trials for anti-OX40 and anti-OX40L antibodies showed promise in reducing inflammation and improving outcomes in conditions like atopic dermatitis. The study highlighted the potential of OX40-targeted therapies in modulating inflammation and autoimmunity, emphasizing the need for careful regulation to balance immune responses.

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