76 N,N-Dimethylglycine Sodium Salt as a Multifaceted Skin Agent Targeting Skin Inflammation, Microvascular Biology, and Senescence-Driven Hair Loss

    November 2025 in “ Journal of Investigative Dermatology ”
    A. Lendvai, Gabriella Béke, Erika Hollósi, Nicole Braun, Carmen Theek, Judit Kállai, Árpád Lányi, Maike Becker, Jörn Michael Völker, Erik Schulze zur Wiesche, Attila Bácsi, Tamás Bı́ró, Johanna Mihály
    TLDR N,N-Dimethylglycine sodium salt may improve skin health and treat hair loss.
    The study investigates the effects of N,N-Dimethylglycine sodium salt (DMG-Na) on human skin cells, revealing its potential as a multifaceted skin treatment. DMG-Na promotes cell proliferation, migration, and VEGF release in HaCaT keratinocytes, while exhibiting anti-inflammatory and antioxidant properties in models of skin diseases. It increases intracellular calcium and nitric oxide production in HDMECs, enhancing skin blood flow. In dermal papilla cells, DMG-Na reverses senescence-associated changes, indicating anti-aging benefits. A pilot study with a 1% DMG-Na gel confirmed its vasodilatory effects. These findings suggest DMG-Na could treat various skin conditions, including hair loss, with further clinical studies underway to assess its broader therapeutic potential.
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