Diphenylcyclopropenone in Severe Alopecia Areata in Children and Adolescents: Long-Term Follow-Up and Relapse Rate

    May 2024 in “ Journal of the Egyptian Womenʼs Dermatologic Society ”
    Yasmin B. El Zawahry, Bakr M. El Zawahry, Dalia Ahmed Bassiouny, Ahmed Soliman, Heba Mohammed Abdel Raheem
    TLDR Diphenylcyclopropenone is effective and safe for treating severe alopecia areata in children, with maintenance therapy reducing relapse risk.
    This study assessed the long-term effectiveness and relapse rates of diphenylcyclopropenone (DPCP) in treating severe alopecia areata (AA) in 144 children and adolescents over 7 years. After 18 months, 65.8% achieved excellent hair regrowth, while 13.7% had moderate regrowth, and 20.5% showed poor response. Relapse rates were higher in those with more extensive disease, and 54.5% of excellent responders experienced relapse, particularly if maintenance therapy was discontinued. The study highlights DPCP as a promising treatment for severe AA in pediatric patients, emphasizing the importance of maintenance therapy to prevent relapse. Side effects were minimal, with severe irritation in 9.7% of patients.
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