Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak

    September 2020 in “ Viruses
    Zheng Yao Low, Isra Ahmad Farouk, Sunil K. Lal
    TLDR Drug repositioning offers a cost-effective, lower-risk way to treat diseases and pandemics like COVID-19.
    The document discussed drug repositioning as an alternative to traditional drug discovery, highlighting its cost-effectiveness and reduced risk due to pre-existing safety and efficacy data. This approach was particularly beneficial for treating rare, orphan, and resistant diseases, as well as urgent pandemic outbreaks like COVID-19. Drugs such as Hydroxychloroquine, Remdesivir, Ivermectin, and Baricitinib were identified as having potential for COVID-19 treatment. The review covered past successes, technological advancements, and ongoing research in drug repositioning, emphasizing its role in personalized medicine and addressing urgent health crises.
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