A Dual-Mechanism Injectable Hydrogel Integrating Reactive Oxygen Species Regulation and Low-Level Laser Therapy for Androgenetic Alopecia Remediation

    July 2026 in “ Journal of Nanobiotechnology ”
    Yi-Xiang Wang, Kang Fu, Yue Yu, Ziyue Xu, Y Zhang, Liu Y, Pengyuan Song, Shuo Sun, Jiaxin Yao, Jie Shen, Ruibo Zhao, Y Li, Xiangdong Kong, Shibo Wang, Li Zhang
    Image of study
    TLDR The hydrogel helps treat hair loss by reducing harmful molecules and improving blood flow to hair follicles.
    The study presents a novel multifunctional hydrogel system designed for the treatment of androgenetic alopecia (AGA), which integrates reactive oxygen species (ROS) regulation and low-level laser therapy. This hydrogel combines multi-active nanozymes and melanin nano photothermal agents to provide a synergistic treatment approach. The nanozymes mimic superoxide dismutase and catalase activities, effectively clearing ROS and restoring redox balance in hair follicles. Concurrently, the photothermal agents enhance follicular metabolic activity and improve local microcirculation under infrared laser irradiation. This dual-mechanism approach aims to improve the follicular microenvironment and promote healthy hair growth, offering a promising multi-target precision therapy for AGA.
    Discuss this study in the Community →