Dupilumab and Alopecia Areata: A Possible Combined or Disturbance Therapy? A Review of the Literature

October 2024 in “ Dermatology Practical & Conceptual ”

Michela Starace, Stephano Cedirian, Federico Quadrelli, Francesca Pampaloni, Tullio Brunetti, Marco Adriano Chessa, Carlotta Gurioli, Bianca Maria Piraccini, Iria Neri

Dupilumab Alopecia Areata Th1 immune profile Th2 immune profile IgE levels Atopic Dermatitis

TLDR Dupilumab may worsen Alopecia Areata in some males but improve it in some females, suggesting personalized treatment is needed.

The review discusses the dual effects of Dupilumab on Alopecia Areata (AA), which are influenced by Th1/Th2 immune profiles. It was observed that Dupilumab worsened AA in males with Th1-driven profiles, whereas females with Th2-skewed profiles experienced improvement. The study highlights that factors such as age, disease severity, and IgE levels may impact treatment outcomes, indicating the necessity for personalized treatment strategies for AA patients with Atopic Dermatitis (AD).

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Research cited in this study

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