A Single-Arm, Open-Label, Phase Ib Clinical Study Evaluating the Efficacy and Safety of Durvalumab in Combination with Albumin-Bound Paclitaxel and Carboplatin as Neoadjuvant Therapy for Resectable Stage III Non-Small Cell Lung Cancer

    January 2025 in “ Recent Patents on Anti-Cancer Drug Discovery ”
    Yuejiao Zhong, Tao Li, Zhaoshi Bai, Ninglei Qiu, Siwen Liu, Wenjia Xia, Qiang Wei, Lingxiang Chen
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    TLDR The treatment showed high response rates and was well-tolerated, potentially extending patient survival.
    This study evaluated the efficacy and safety of durvalumab combined with albumin-bound paclitaxel and carboplatin as neoadjuvant therapy for 40 patients with resectable stage III Non-small Cell Lung Cancer (NSCLC). The treatment achieved a 65% Objective Response Rate (ORR), with 67.5% of patients achieving Major Pathological Response (MPR) and 22.5% achieving Complete Pathological Response (pCR). The expression of PD-1 on T lymphocytes significantly decreased post-treatment, indicating improved immune function. Common adverse events included hair loss (47.5%), nausea and vomiting (42.5%), and fatigue (40%), mostly grades 1 and 2. The average Disease-Free Survival (DFS) was 21.49 months, and Overall Survival (OS) was 24.79 months. The treatment showed a high pathological response rate and good tolerability, suggesting potential for extending patient survival.
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