Mechanistic Insights on Dyspepsia Modulation by Salvia Rosmarinus Through Network Pharmacology, Molecular Docking, and Molecular Dynamics

The study explores the potential of Salvia rosmarinus (rosemary) in treating dyspepsia through network pharmacology, molecular docking, and molecular dynamics. It identifies significant interactions between rosemary compounds and dyspepsia-related genes, with luteolin showing strong binding affinity and stability, surpassing conventional treatments like omeprazole and lansoprazole. The research highlights the role of protein-protein interactions and pathway enrichment, particularly involving the proto-oncogene c-Kit, suggesting that rosemary's bioactive compounds could serve as a basis for developing pharmaceuticals targeting gastrointestinal diseases like dyspepsia. The findings indicate that luteolin, with its favorable bioavailability and reduced side effects, could be a promising natural therapeutic agent for functional dyspepsia.