Mechanistic Insights on Dyspepsia Modulation by Salvia Rosmarinus Through Network Pharmacology, Molecular Docking, and Molecular Dynamics

This study investigates the potential of Salvia rosmarinus (rosemary) in modulating dyspepsia through network pharmacology, molecular docking, and molecular dynamics. The research identifies significant interactions between rosemary compounds and dyspepsia-related genes, particularly highlighting luteolin's role in promoting apoptosis in cancer pathways, thereby reducing the risk of gastric cancer. Molecular dynamics simulations further validate the stability and binding behavior of luteolin, suggesting its potential as a basis for developing pharmaceuticals targeting gastrointestinal diseases like dyspepsia.