Effect of Prostaglandin D2 on Hair Follicle Growth and Its Impact on Hair Follicle Stem/Progenitor Cells

    April 2016 in “ Journal of Investigative Dermatology ”
    Ying Zheng, Ju-Ton Hsieh, H. Rosengard, Arben Nace, Gang Ma, Mikhail Geyfman, Serge Lichtsteiner, Ken Washenik, George Cotsarelis
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    TLDR Blocking Prostaglandin D₂ may help treat hair loss.
    The study from May 2016 investigated the role of Prostaglandin D₂ (PGD₂) in hair loss, particularly in men with androgenetic alopecia, and found that PGD₂ levels were higher in balding scalp areas. The use of PTGDR2 antagonists was able to counteract the negative effects of PGD₂, promoting hair growth by preventing apoptosis and sustaining keratinocyte proliferation. In mice, applying PGD₂ shortened the hair growth phase and hastened the transition to the hair shedding phase, while PTGDR2 antagonists had the opposite effect, leading to longer hair. The study also showed that PGD₂ reduced the expression of hair follicle progenitor cell markers and decreased the number of proliferating cells in the hair germ population, indicating that PGD₂ inhibits hair progenitor cell activation. These findings suggest that blocking PGD₂'s effects could be a potential treatment for hair loss.
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      community DNA test result is incredible !

      in Technology  27 upvotes 1 week ago
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      community Need supplemental products in addition to oral minoxidil and oral dutasteride

      in Product  1 upvotes 4 months ago
      The user has been using oral minoxidil and dutasteride for hair loss without success and is considering adding topical 17α-estradiol, Pyrilutamide, Clascoterone, or cetirizine. They have confirmed low serum DHT levels and are exploring additional treatments due to genetic sensitivity to DHT and prostaglandin D2.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  58 upvotes 10 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

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