Effect of PTPN22, FAS/FASL, IL2RA and CTLA4 genetic polymorphisms on the risk of developing alopecia areata: A systematic review of the literature and meta-analysis

November 2021 in “ PLoS ONE ”

Sebastián Ramiro Gil-Quiñones, I. T. Sepúlveda-Pachón, Guillermo Sánchez, Luz Dary Gutiérrez-Castañeda

TLDR The T allele of the PTPN22 gene may increase the risk of alopecia areata.

This systematic review and meta-analysis aimed to assess the impact of specific gene polymorphisms on alopecia areata (AA) susceptibility. The study analyzed 18 articles qualitatively and 16 quantitatively, focusing on the FAS, FASL, PTPN22, CTLA4, and IL2RA genes. A significant association was found between the rs2476601 polymorphism in the PTPN22 gene and an increased risk of developing AA, with an odds ratio of 1.49 in the allelic model. However, no association was found for the other gene polymorphisms studied. The findings suggested that the T allele of the SNP rs2476601 in the PTPN22 gene could be a risk factor for AA, but emphasized the need for more studies considering ethnic backgrounds to validate these results and further investigate the role of the other genetic variants.

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