Therapeutic Hotline: Effectiveness of the Association of Cetirizine and Topical Steroids in Lichen Planus Pilaris - An Open-Label Clinical Trial

This open-label clinical trial investigated the effectiveness of combining cetirizine (CTZ) and topical steroids in treating lichen planus pilaris (LPP) of the scalp, a condition leading to scarring alopecia. Twenty-one patients were treated with 30 mg of CTZ daily alongside topical steroids. The treatment stabilized the condition in 18 patients, reducing inflammation and symptoms such as erythema, follicular hyperkeratosis, and hair loss. One patient discontinued due to cardiac arrhythmia after 3 months. The study concluded that this combined therapy could be a safe and effective option for managing severe LPP cases.