Clinical Effectiveness of Ethinylestradiol-Cyproterone Acetate and Raloxifene Combination Therapy in Polycystic Ovary Syndrome-Associated Infertility

January 2025 in “ American Journal of Translational Research ”

Pengyu Huang

ethinylestradiol-cyproterone acetate raloxifene polycystic ovary syndrome PCOS infertility sex hormones ovarian function endometrial receptivity EE-CPA

TLDR The combination therapy effectively treats infertility in PCOS without major side effects.

The study demonstrates that the combination therapy of ethinylestradiol-cyproterone acetate (EE-CPA) and raloxifene is highly effective in treating infertility associated with polycystic ovary syndrome (PCOS). This therapy improves therapeutic outcomes by enhancing metabolism, sex hormones, ovarian function, and endometrial receptivity, which collectively lead to better pregnancy outcomes. Importantly, these benefits are achieved without a significant increase in adverse effects.

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