Effects of CO2 Fractional Laser on Hair Growth in C57BL/6 Mice and Potential Underlying Mechanisms

March 2019 in “ Chinese Medical Journal ”

Fenglin Zhuo, Linfeng Li, Liangqi Cai, Yue Huang

CO2 fractional laser hair growth inflammatory cytokines Wnt signal pathway Wnt10b β-catenin ablative CO2 fractional laser therapy carbon dioxide fractional laser hair regrowth inflammatory proteins Wnt pathway beta-catenin

TLDR CO2 fractional laser therapy may help regrow hair without scarring by affecting certain inflammatory and growth-related molecules.

In 2019, a study involving 60 C57BL/6 mice investigated the effects of CO2 fractional laser on hair growth and the potential underlying mechanisms. The study found that the laser treatment induced hair re-growth and scar formation in a dose-dependent manner, with the most effective dosage being 18 mJ/spot and 361 spots/cm2, which promoted hair re-growth without causing scarring. The expression of several inflammatory cytokines and Wnt signal pathway molecules, including Wnt10b and β-catenin, increased after laser treatment, suggesting their role in hair re-growth. The study concluded that ablative CO2 fractional laser therapy could potentially serve as a supplementary or alternative treatment for hair loss.

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Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

Effects of CO2 Fractional Laser on Hair Growth in C57BL/6 Mice and Potential Underlying Mechanisms

Research cited in this study

research Fractional Non-Ablative Laser-Assisted Drug Delivery Leads to Improvement in Male and Female Pattern Hair Loss

research Aging in Hair Follicle Stem Cells and Niche Microenvironment

research Enhancing Hair Growth in Male Androgenetic Alopecia by a Combination of Fractional CO2 Laser Therapy and Hair Growth Factors

research Low-Level Laser Therapy as a Treatment for Androgenetic Alopecia

research Enhancing Hair Follicle Regeneration by Nonablative Fractional Laser: Assessment of Irradiation Parameters and Tissue Response

research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

research Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

research New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis