Effects of Glucagon-like Peptide-1 Receptor Agonists on Skin Homeostasis and Skin Aging Processes

The document examines the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on skin health and aging, noting both potential benefits and adverse effects. While GLP-1 RAs may enhance wound healing and reduce inflammation, they are also linked to accelerated facial skin aging, known as "Ozempic face," due to rapid weight loss and reduced subcutaneous fat. This can lead to skin dehydration, sagging, thinning, and hair loss. These changes may result from nutrient deficiencies, hormonal alterations, and impaired collagen synthesis. Although experimental data suggest these mechanisms, the clinical significance for human skin aging is not yet clear, necessitating further research.