Effects of Testosterone, Dihydrotestosterone and Estradiol on the Growth Behavior of Cultured Hair Bulb Papilla Cells and Root Sheath Fibroblasts

The study investigated the effects of testosterone, dihydrotestosterone, and estradiol on the growth of cultured hair bulb papilla cells and root sheath fibroblasts from three healthy male subjects. It was found that both testosterone and dihydrotestosterone inhibited the growth rates of these cells, with a more pronounced effect on hair bulb papilla cells at higher doses. Estradiol did not affect the growth of either cell type.