TLDR Prenatal retinoic acid exposure did not affect mouse vibrissal follicle development.
The study investigated the effects of prenatal exposure to all-trans-retinoic acid (RA) on the development of vibrissal follicles in NMRI mice. A single oral dose of 30 mg/kg body weight of RA was administered on day 11.5 of gestation. The results showed no fetal malformations and no significant differences in the histological features or keratin protein distribution between untreated, vehicle-treated, and RA-treated mice. The absence of teratogenic effects suggests that this protocol could be useful for studying the impact of prenatal RA exposure on postnatal skin tumor development in mice.
16 citations
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November 1994 in “Developmental Biology” Retinoic acid causes gland formation instead of hair in mouse skin by altering epidermal and dermal interactions.
18 citations
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June 1993 in “Archives of Dermatological Research” Human hair follicles can be used to create skin-like tissue for wound healing and drug testing.
156 citations
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January 1989 in “Genes & Development” Keratin expression reflects cell organization and differentiation, not causes it.
248 citations
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73 citations
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50 citations
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July 2008 in “British Journal of Dermatology” 138 citations
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276 citations
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199 citations
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29 citations
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