TLDR GT20029 helps regrow hair in men with hair loss and is well-tolerated.
The study assessed the efficacy and safety of topical GT20029 in 180 Chinese adult males with androgenetic alopecia over 12 weeks. Participants were divided into groups receiving either GT20029 (0.5% or 1.0%) or placebo. Results indicated significant increases in target area non-vellus hair count for all GT20029-treated groups, with the 0.5% QD and 1.0% BIW groups showing notable improvement over placebo. Hair width also improved significantly in the 1.0% BIW group. The incidence of adverse events was similar across all groups and mostly mild. The study concluded that GT20029 is effective for hair regrowth with good tolerability, suggesting it as a promising non-hormonal topical alternative for AGA treatment, warranting further research.
January 2023 in “Frontiers in Medicine” ALRV5XR is the most effective hair regrowth treatment at 24 weeks.
23 citations
,
January 2021 in “Biomedicine & Pharmacotherapy” DHT stops hair regrowth in mice, similar to human hair loss.
17 citations
,
October 2013 in “Plastic and reconstructive surgery. Global open” Male pattern baldness may be caused by scalp pressure on hair follicles, which increases with age and leads to a cycle of hair loss. This process is not directly determined by genes.
115 citations
,
September 2012 in “Experimental Dermatology” Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.
124 citations
,
July 2012 in “Archives of Dermatological Research” Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.
November 2025 in “Journal of Medicinal Chemistry” Topical PROTACs show promise for treating skin conditions but need better stability and delivery methods.
July 2024 in “Forum Dermatologicum” Topical treatments for hair loss can be effective but need careful safety evaluation.
1 citations
,
January 2022 in “Journal of Biosciences and Medicines” Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.
Topical GT20029 effectively promotes hair regrowth and is well-tolerated.
Recent research on androgenetic alopecia focuses on optimizing treatments, with promising new therapies emerging.
