Efficacy of Different Doses of Platelet-Rich Plasma for Moderate Carpal Tunnel Syndrome: Study Protocol for a Prospective, Randomized, Controlled Trial in Guangzhou, China

This study protocol describes a prospective, double-blind, randomized, controlled trial in Guangzhou, China, involving 60 adults with moderate carpal tunnel syndrome (CTS) to evaluate the efficacy of different doses of platelet-rich plasma (PRP) injections (3 mL vs. 5 mL) around the median nerve. The primary outcome is the change in numbness score on a Visual Analogue Scale from baseline to 6 months. Secondary outcomes include changes in ultrasound parameters, symptom severity, functional status, and electrophysiological measures. The study aims to determine the optimal PRP dosage for symptom relief in moderate CTS patients, providing guidance for clinical application. Limitations include a single-center design and a 6-month follow-up period.