Comparison of Therapeutic Efficacy of Topical Tacrolimus 0.1% and Topical Dithranol 0.5% in Treatment of Alopecia Areata

    May 2025 in “ Pakistan Armed Forces Medical Journal ”
    Mohammed A Husain, Muhammad Adeel Siddiqui, Hina Mazhar, Zafar A. Sheikh, Adiba, Kashifa Yasmeen
    TLDR Dithranol is more effective than Tacrolimus for hair regrowth in alopecia areata.
    This study compared the therapeutic efficacy of topical Tacrolimus 0.1% and topical Dithranol 0.5% in treating alopecia areata over 24 weeks. Conducted at Combined Military Hospitals in Hyderabad and Abbottabad, the study involved patients divided into two groups: Group A received Tacrolimus, and Group B received Dithranol. Results showed that more than 80% hair regrowth was observed in 23.33% of patients in the Tacrolimus group and 40% in the Dithranol group. The study concluded that Dithranol is more effective than Tacrolimus, with a significant p-value of 0.039.
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