Efficacy and Safety of a Proprietary Free Fatty Acid Rich Saw Palmetto Extract (USPlus® PRO) for Lower Urinary Tract Symptoms in Males: A Randomized, Double-Blind, Placebo-Controlled Trial

January 2026 in “ Food and Nutrition Sciences ”

Amanda Rao, Leigh Vinocur, Janice Pellow, David Briskey

saw palmetto extract free fatty acid lower urinary tract symptoms International Prostate Symptom Score USPlus PRO

TLDR USPlus PRO saw palmetto extract improves urinary symptoms and is safe for men.

This study evaluated the efficacy and safety of USPlus PRO saw palmetto extract on lower urinary tract symptoms (LUTS) in 80 males aged 45-80. Over 12 weeks, participants received either the extract or a placebo. Results from 62 participants showed significant improvements in the USPlus PRO group, including reductions in the International Prostate Symptom Score (IPSS) and enhancements in sexual function. Notable improvements were seen in voiding symptoms, incomplete emptying, and weak stream. The extract demonstrated a favorable safety profile, suggesting it may be a beneficial treatment for LUTS.

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community Here are the results from my journey! I used saw palmetto tablets instead of Finasteride(I was afraid of using it), 5% Minoxidil spray and Derma Pen once a week 1.5mm.

in Progress Pictures 306 upvotes 2 years ago

The user shared their positive hair regrowth experience using saw palmetto tablets, 5% minoxidil spray, and a Derma Pen. The conversation debates the effectiveness of saw palmetto versus finasteride, with some advocating for natural treatments and others emphasizing the proven results of finasteride and minoxidil, often in combination with microneedling.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community 5-Months Update: Minoxidil + Red Light Therapy + Lifestyle Changes

in Progress Pictures 1031 upvotes 1 year ago

The user reported positive hair regrowth after 5 months using Minoxidil, red light therapy, and lifestyle changes, including dietary improvements and stress reduction. They chose natural supplements like saw palmetto and beta-sitosterol over pharmaceutical DHT inhibitors like finasteride.

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in Finasteride/Dutasteride 278 upvotes 2 years ago

The conversation is about the side effects of finasteride, including Post Finasteride Syndrome, with varied personal experiences and differing views on the credibility of information sources. Some participants also discuss using minoxidil as a hair loss treatment.

community My way to recovery and advice - Hope this helps (m20)

in Product 6 upvotes 11 months ago

A 20-year-old shared their experience of reversing hair loss without using minoxidil or finasteride, instead relying on supplements like biotin, collagen, fish oil, saw palmetto, and various vitamins. They emphasized the importance of a balanced supplement schedule and noted improvements in hair health without experiencing additional shedding.

community Insane hairline regrowth with natural supps and minox

in Update 105 upvotes 1 week ago

A 23-year-old achieved significant hairline regrowth using minoxidil, saw palmetto, collagen peptides, biotin, omega-3, iron, ketoconazole shampoo, and scalp care techniques, without finasteride or dutasteride. The user attributes success to this combination but is unsure which element is most effective.

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