The Relative Efficacy and Safety of Monotherapies for Alopecia Areata: A Network Meta-Analysis Study

April 2025 in “ Journal of Cosmetic Dermatology ”

Aditya K. Gupta, Mary A. Bamimore, Paradi Mirmirani, Vincent Piguet, Mesbah Talukder

Alopecia Areata Janus kinase inhibitors JAK inhibitors FDA AA JAKIs

TLDR Janus kinase inhibitors are effective and safe for treating Alopecia Areata.

The study conducted a network meta-analysis to evaluate the relative efficacy and safety of monotherapies for Alopecia Areata (AA), focusing on 8 different Janus kinase inhibitors (JAKIs), including those approved by the FDA. The high-quality evidence generated from this analysis aims to assist clinicians in making informed decisions and updating medical practice guidelines for treating AA.

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Research cited in this study

13 / 13 results

research Comparative Efficacy and Safety of Systemic Steroids, Oral JAK Inhibitors, and Contact Immunotherapy in the Treatment of Severe Alopecia Areata: A Systematic Review and Network Meta-Analysis

3 citations , July 2024 in “Archives of Dermatological Research”

Oral ritlecitinib and baricitinib are promising treatments for severe alopecia areata due to their balance of effectiveness and safety.

research Efficacy and Safety of Deuruxolitinib, an Oral Selective Janus Kinase Inhibitor, in Adults with Alopecia Areata: Results from the Phase 3 Randomized, Controlled Trial (THRIVE-AA1)

63 citations , July 2024 in “Journal of the American Academy of Dermatology”

Comparative Efficacy and Safety of JAK Inhibitors in the Treatment of Moderate-to-Severe Alopecia Areata: A Systematic Review and Network Meta-Analysis

research Comparative Efficacy and Safety of JAK Inhibitors in the Treatment of Moderate-to-Severe Alopecia Areata: A Systematic Review and Network Meta-Analysis

April 2024 in “Frontiers in pharmacology”

Brepocitinib 30mg is most effective for moderate-to-severe alopecia areata, but ritlecitinib 50mg may offer a better balance of safety and effectiveness.

research Visualizing Severity Of Alopecia Tool Scores In The Clinical Setting Using Patient Images From A Clinical Trial

January 2024 in “JEADV clinical practice”

The study helps doctors use patient images to understand and apply SALT scores for treating severe alopecia areata.

The Relative Efficacy of Monotherapy With Janus Kinase Inhibitors, Dupilumab and Apremilast in Adults With Alopecia Areata: Network Meta-Analyses of Clinical Trials

research The Relative Efficacy of Monotherapy With Janus Kinase Inhibitors, Dupilumab and Apremilast in Adults With Alopecia Areata: Network Meta-Analyses of Clinical Trials

2 citations , July 2023 in “Journal of cosmetic dermatology”

JAK inhibitors are more effective and safer for treating alopecia areata than dupilumab and apremilast.

research Efficacy and Safety of Different JAK Inhibitors in the Treatment of Alopecia Areata: A Network Meta-Analysis

7 citations , April 2023 in “Frontiers in immunology”

Oral baricitinib and ruxolitinib are effective and safe for treating alopecia areata.

research Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial

227 citations , April 2023 in “The Lancet”

research Alopecia Areata and Risk of Atopic and Autoimmune Conditions: Population-Based Cohort Study

34 citations , November 2022 in “Clinical and Experimental Dermatology”

People with alopecia areata are more likely to have other immune-related conditions.

research Two Phase 3 Trials of Baricitinib for Alopecia Areata

148 citations , March 2022 in “The New England Journal of Medicine”

Baricitinib was effective in treating alopecia areata in two major trials.

research A Phase 2a Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of the Oral Janus Kinase Inhibitors Ritlecitinib and Brepocitinib in Alopecia Areata: 24-Week Results

138 citations , March 2021 in “Journal of the American Academy of Dermatology”

Ritlecitinib and brepocitinib effectively regrow hair in alopecia areata patients.

Chinese SLE Treatment and Research Group Registry XIII: Prevalence and Risk Factors for Chronic Scarring Alopecia in Patients with Systemic Lupus Erythematosus

research Chinese SLE Treatment and Research Group Registry XIII: Prevalence and Risk Factors for Chronic Scarring Alopecia in Patients with Systemic Lupus Erythematosus

1 citations , January 2021 in “Arthritis Research & Therapy”

About 8% of people with systemic lupus erythematosus have chronic scarring alopecia, with certain symptoms and positive antibodies increasing the risk, while immunosuppressants may lower it.

research Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study

66 citations , December 2018 in “Dermatology”

Both ruxolitinib and tofacitinib are effective and safe for treating severe alopecia areata, but relapses are common.

A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata

research A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata

42 citations , November 2018 in “Archives of dermatological research”

Apremilast was not effective in treating moderate-to-severe alopecia areata.

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research Serum Zinc Concentration in Patients With Alopecia Areata

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research Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib

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