Epigallocatechin-Gallate (EGCG): An Essential Molecule for Human Health and Well-Being

September 2025 in “ International Journal of Molecular Sciences ”

Emanuele Rovaldi, Violante Di Donato, Giovanni Paolino, Maria Giuseppina Bruno, Alessia Medei, Steven Paul Nisticò, Giovanni Pellacani, Norbert Kiss, Giulia Azzella, András Bánvölgyi, Carmen Cantisani

epigallocatechin-gallate EGCG green tea alopecia 5α-reductase dermal papilla cells antioxidant anti-inflammatory anti-apoptotic green tea extract

TLDR EGCG in green tea benefits skin, hair, cancer treatment, weight loss, diabetes, heart, and brain health.

Epigallocatechin-gallate (EGCG), a catechin in green tea, offers extensive health benefits, particularly in dermatology and oncology. It shows promise in treating skin conditions like acne, alopecia, and UV-induced damage, and enhances hair growth by inhibiting 5α-reductase and supporting dermal papilla cells. EGCG also exhibits anti-cancer properties by inhibiting cancer cell proliferation and enhancing chemotherapy efficacy. It aids in weight loss, diabetes management, cardiovascular health, and neuroprotection. EGCG's antioxidant, anti-inflammatory, and anti-apoptotic effects make it a valuable compound for promoting overall health and well-being, with potential applications in aesthetic medicine and as a supportive agent in cancer therapy.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG)

108 citations , November 2006 in “Phytomedicine”

Green tea component EGCG could potentially promote human hair growth.

Similar Research

5 / 421 results

5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment

research A Study on the Effectiveness and Safety of Herbal Extract Combination Compared to 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A Randomized, Double-Blind, Controlled Trial

June 2024 in “The Open dermatology journal”

The herbal extract is as effective and safe as 3% minoxidil for treating hair loss.

research Phytochemicals and Novel Delivery Systems in Alopecia Management: An Integrative Review

December 2025 in “Phytomedicine Plus”

Combining herbal medicines with modern delivery systems may improve alopecia treatment.

Epigallocatechin-Gallate (EGCG): An Essential Molecule for Human Health and Well-Being

Research cited in this study

research Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG)

Related Community Posts Join

community Natural Remedies: Polyphenols and Hair Loss

community Creating Custom Topicals: A Guide (2025 Edition)

community Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles - PubMed

community This serum outperformed Minoxidil in a recent study. Please debunk

Similar Research

research 5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment

research The Future of Alopecia Treatment: Plant Extracts, Nanocarriers, and 3D Bioprinting in Focus

research Undariopsis Peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways

research A Study on the Effectiveness and Safety of Herbal Extract Combination Compared to 3% Minoxidil Solution for the Treatment of Androgenetic Alopecia: A Randomized, Double-Blind, Controlled Trial

research Phytochemicals and Novel Delivery Systems in Alopecia Management: An Integrative Review