P25 ELF5 Regulation of Normal Skin Development and Homeostasis

The study investigates the role of E74-like factor (ELF)5 in skin development and homeostasis, focusing on its expression in basal and suprabasal layers of the epidermis and hair follicles. ELF5 is identified as a crucial regulator of stem/progenitor cell functions, influencing keratinocyte differentiation and proliferation. The research includes in vitro studies using primary human keratinocytes and RNA sequencing to explore ELF5's molecular targets. The findings lay a foundation for further research into ELF5's regulatory mechanisms, with implications for regenerative medicine and aging.