Emergency Wound Infection Monitoring and Treatment Based on Wearable Electrochemical Detection and Drug Release with Conductive Hydrogel

The study introduces a novel wearable system for emergency wound infection monitoring and treatment, utilizing a conductive hydrogel integrated with sensors to detect biomarkers like uric acid, pH, and temperature. This system employs silver nanoparticles for antibacterial protection and amikacin-loaded cationic liposomes for controlled drug release. The hydrogel's electrical stimulation enables precise drug delivery, enhancing antibacterial activity against pathogens such as E. coli and S. aureus. In vivo experiments on rats showed effective wound healing, demonstrating the system's potential for advanced wound care. The approach aims to improve treatment efficacy, reduce antibiotic misuse, and enhance healing outcomes in emergency scenarios.