Endocrine Correlates of Male Breast Cancer Risk: A Case-Control Study in Athens, Greece

This study in Athens, Greece, investigated the link between endocrine factors and male breast cancer risk, involving 23 cases and 76 controls. It found that smoking, birth order, and frequency of orgasms in later life were inversely associated with the risk, suggesting a role of endocrine factors in the disease's etiology. The study supported the idea that increased estrogen production and reduced sexual drive might be linked to male breast cancer. Despite its small size, it confirmed known risk factors like being single, childless, or having gynecomastia, and found no occupational risks. The findings indicated that reduced sexual drive was associated with male breast cancer, while anti-estrogenic influences might reduce the risk.