Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society* Clinical Practice Guideline

September 2017 in “ The Journal of Clinical Endocrinology & Metabolism ”

Wylie C. Hembree, Peggy T. Cohen‐Kettenis, Louis Gooren, Sabine E Hannema, Walter J. Meyer, M. Hassan Murad, Stephen M. Rosenthal, Joshua D. Safer, Vin Tangpricha, Guy T’Sjoen

The updated 2017 guideline from the Endocrine Society emphasized the importance of a multidisciplinary approach in the endocrine treatment of gender-dysphoric/gender-incongruent individuals, highlighting the role of endocrinologists in developing physical characteristics of the affirmed gender. It recommended against hormone treatment for prepubertal individuals but supported the use of gonadotropin-releasing hormone agonists for adolescents at Tanner Stage G2/B2, with gender-affirming hormones added after confirming persistent gender dysphoria and informed consent. The guideline stressed the need for expert multidisciplinary teams for adolescents and adults, monitoring hormone levels, and managing risks and complications. It also advised caution in hormone treatment for individuals without gender dysphoria to avoid unnecessary harm.

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