Engineering a bacterial polysaccharide-based metal–organic framework-enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing

The study developed a novel bioactive 3D hydrogel enhanced with bacterial polysaccharide-based metal-organic frameworks (MOFs) for accelerated full-thickness wound healing. The hydrogel, composed of gellan gum, zein, copper MOFs, and tannic acid, demonstrated significant antioxidant and antibacterial properties, promoting re-epithelialization, neovascularization, and hair follicle formation. It showed high biocompatibility with L929 fibroblast cells and effectively accelerated wound healing in rats, leaving only 1.6% of the wound area untreated. The GG-Z-TA/M1 formulation was identified as the most biocompatible, achieving nearly complete healing by day 21. The study concludes that these hydrogels are promising candidates for complex wound management due to their multifunctional properties.