Functionally Enhanced Placenta-Derived Mesenchymal Stem Cells Inhibit Adipogenesis in Orbital Fibroblasts With Graves’ Ophthalmopathy

    November 2020 in “ Stem Cell Research & Therapy ”
    Jae Yeon Kim, Sohae Park, Hyun-Jung Lee, Helen Lew, Gi Jin Kim
    TLDR Enhanced stem cells from the placenta can help treat Graves' eye disease by stopping fat cell growth.
    The study explored the impact of PRL-1-overexpressing placenta-derived mesenchymal stem cells (PD-MSCsPRL-1) on adipogenesis in orbital fibroblasts from patients with Graves’ ophthalmopathy (GO). Involving 3 patients with GO and 3 controls, the research found that PD-MSCsPRL-1 significantly reduced lipid accumulation and adipogenic marker expression in these fibroblasts. This effect was mediated by the secretion of insulin-like growth factor-binding proteins, which modulated key signaling pathways. The modified PD-MSCs maintained their stemness and did not form teratomas, indicating safety and stability. The study concluded that PD-MSCsPRL-1 could offer a novel therapeutic strategy for GO by targeting adipogenesis and inflammation.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 13 results

      community Finasteride and fertility. Personal report.

      in Finasteride/Dutasteride  829 upvotes 10 months ago
      Finasteride can affect sperm quality, but fertility usually returns after stopping it, as shown by a user who conceived four months after discontinuation. Some users successfully conceive while on finasteride, though some prefer to pause its use to minimize risks.

      community Which mesotherapy should I choose?

      in Research/Science  1 upvotes 1 year ago
      A user is considering adding PRP and mesotherapy to their hair loss treatment and is deciding between two options: Promoitalia, which contains Phosphatidic acid, Riboflavin, and Superoxide dismutase, and the more expensive Melsmon, a human placenta derivative. They seek advice on which option to choose based on effectiveness and scientific backing.

      community 1.5 Year Hair Restoration Journey - Stem Cells, PRP, Minoxidil, Topical Finasteride

      in Progress Pictures  26 upvotes 1 year ago
      A user shared their 1.5-year hair restoration journey, successfully using mesenchymal stem cell therapy, Platelet Rich Plasma (PRP) injections, and a topical compound of finasteride and minoxidil, avoiding a hair transplant and oral finasteride. They experienced significant hair regrowth, particularly crediting the stem cell therapy for quick initial results.

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  301 upvotes 2 years ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

      community I got an idea to cure baldness but i need your help

      in Satire  94 upvotes 2 years ago
      User suggests finding unknown baldness cure by applying random items on scalp and reporting results after 6 months. Various users humorously agree to try different substances, including whale sperm and hydrochloric acid.

    Similar Research

    5 / 1000+ results