Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

The document reviewed advancements in transdermal drug delivery systems (TDDS) using nanocarriers to enhance drug permeation through the skin. It highlighted the challenges posed by the skin's stratum corneum and explored various strategies, including chemical enhancers and physical methods like iontophoresis and ultrasound, to improve drug penetration. Nanocarriers, such as liposomes and nanoparticles, were emphasized for their ability to enhance drug diffusion, stabilization, and sustained delivery, with a focus on lipid-based nanoparticles for targeting hair follicles, which could be beneficial for conditions like androgenetic alopecia. Despite their advantages, challenges like compatibility and solubility needed addressing. The document underscored the need for further research to validate these methods in human models to ensure safe and effective transdermal drug delivery.