Enhancing Hair Follicle Growth: Investigating the Synergistic Effects of Ursolic and Shikimic Acid Through In Vitro Testing on Dermal Papilla Cells

The study investigates the effects of ursolic and shikimic acid on hair follicle growth using in vitro testing on dermal papilla cells. It focuses on the biological activity of Illicium verum and Ocimum sanctum L., both individually and in combination. The research found that the combination of these botanical extracts significantly increased the expression of the insulin-like growth factor-1 (IGF-1) gene and inhibited the tumor necrosis growth factor (TGF-β1) gene more effectively than when tested alone. These results suggest a synergistic effect of the combination, promoting hair growth by enhancing IGF-1 expression and reducing TGF-β1 expression.