Homeostasis, Regeneration, And Tumor Formation In The Mammalian Epidermis

    Daria Belokhvostova, Ieva Berzanskyte, Ana-Maria Cujba, Geraldine M. Jowett, Lucy Marshall, Johanna Prueller, Fiona M. Watt
    TLDR Stem cells in the skin help with healing and can also lead to cancer.
    The review discussed the role of stem cells in the maintenance, repair, and tumor formation of the mammalian epidermis. It highlighted how technological advances like single-cell transcriptomics and in vivo imaging provided new insights into the plasticity and function of epidermal stem cells. These stem cells were crucial for maintaining homeostasis, aiding in wound repair, and potentially contributing to cancer development. The study emphasized the importance of understanding the stem cell compartment's nature and its varying roles in different physiological and pathological contexts.
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