Transplanted Epidermal Neural Crest Stem Cell in a Peripheral Nerve Gap

April 2014 in “ PubMed ”

Lu Zhang, Jieyuan Zhang, Bingcang Li, Zheng Liu, Bin Liu

epidermal neural crest stem cells EPI-NCSC hair follicles PLGA conduit sciatic nerve peripheral nerve injuries

TLDR Epidermal neural crest stem cells from hair follicles can help repair nerve injuries.

The study investigated the use of epidermal neural crest stem cells (EPI-NCSC) derived from hair follicles to repair peripheral nerve injuries in rats. EPI-NCSC were cultured and then used to fill a poly lactic acid coglycolic acid copolymer (PLGA) conduit, which was applied to a 10 mm gap in the rat sciatic nerve. After 4 weeks, the treated nerves showed histological restoration, partial recovery of sensory function, and improved sciatic nerve index compared to controls. The results suggested that EPI-NCSC in a PLGA conduit effectively supported peripheral nerve repair.

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