Single-Stage Transplantation with Epidermal Stem Cells Enhances Survival of Tissue-Engineered Skin by Inducing Early Angiogenesis

    March 2023 in “ Stem Cell Research & Therapy ”
    Zhiyong Wang, Hailin Xu, Hao Yang, Yi Zhang, Xiaoyan Wang, Peng Wang, Zhongye Xu, Dongming Lv, Yanchao Rong, Yunxian Dong, Bing Tang, Zhicheng Hu, Wuguo Deng, Jiayuan Zhu
    TLDR Epidermal stem cells improve skin graft survival by promoting early blood vessel formation.
    The study investigated the role of epidermal stem cells (EpSCs) in promoting early angiogenesis and improving the survival of tissue-engineered skin in a single-stage transplantation process. Using 75 rats divided into five groups, the research demonstrated that EpSCs enhanced angiogenesis and epithelialization in acellular dermal matrix (ADM) implants. The group receiving ADM, split-thickness skin graft (STSG), and EpSCs (ASE) showed significantly better outcomes in terms of skin graft survival, reduced contraction, and cosmetic appearance compared to other groups. The findings suggested that EpSCs could facilitate the formation of new blood vessels in dermal substitutes, supporting the potential for one-step transplantation in clinical applications.
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