Single-Stage Transplantation with Epidermal Stem Cells Enhances Survival of Tissue-Engineered Skin by Inducing Early Angiogenesis

    March 2023 in “ Stem Cell Research & Therapy ”
    Zhiyong Wang, Hailin Xu, Hao Yang, Yi Zhang, Xiaoyan Wang, Peng Wang, Zhongye Xu, Dongming Lv, Yanchao Rong, Yunxian Dong, Bing Tang, Zhicheng Hu, Wuguo Deng, Jiayuan Zhu
    TLDR Epidermal stem cells improve skin graft survival by promoting early blood vessel formation.
    The study investigated a novel tissue-engineered skin construct combining acellular dermal matrix (ADM), split-thickness skin grafts (STSG), and epidermal stem cells (EpSCs) to enhance wound healing in rats. The combination, referred to as ASE, promoted rapid vascularization and improved healing outcomes by inducing early angiogenesis. The research involved 75 adult male Sprague-Dawley rats and demonstrated that the ASE construct significantly improved wound healing, epithelialization, and collagen remodeling compared to controls. The study concluded that the EpSCs and ADM combination provided superior proangiogenic effects, leading to enhanced survival and vascularization of tissue-engineered skin grafts, with potential clinical applications for skin regeneration.
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