Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation

The study found that ebastine, a second-generation antihistamine, significantly increased the proliferation of human follicle dermal papilla cells (HFDPC) by activating the ERK signaling pathway, without causing cell death or morphological changes. This effect was dose-dependent and involved the upregulation of cell cycle regulatory proteins and anti-apoptotic factors. The research suggested that ebastine could potentially aid in hair regrowth and treat baldness by promoting HFDPC proliferation and possibly inhibiting T cell migration in alopecia areata. Further in vivo studies were recommended to explore ebastine's potential as a treatment for hair loss.