Microcirculation-Promoting Effect of Escin on Cutaneous Tissue via GSK3β Down-Regulation

    October 2025 in “ Current Issues in Molecular Biology ”
    Jaeyoon Kim, Jang Ho Joo, Heena Rim, Sung Hyun Kim, Jae Young Shin, Seung‐Hyun Jun, Nae‐Gyu Kang
    TLDR Escin improves skin blood flow and health by enhancing blood vessel networks.
    This study explores the effects of escin on cutaneous microcirculation, highlighting its molecular mechanisms. Escin enhances blood flow in skin tissue by modulating the Wnt/β-Catenin signaling pathway through the down-regulation of Gsk3β. Involving 31 Korean volunteers, the study showed that topical application of escin, combined with adenosine, significantly improved skin blood flow. Escin's activation of the Wnt/β-catenin and Wnt/PCP signaling pathways promotes vascular network formation, suggesting its potential as a therapeutic agent for improving skin health and treating conditions like androgenetic alopecia, due to its role in hair follicle cycling.
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