Effect of Ethanol Extract of Zapoteca Portoricensis Stem on Liver, Kidney, and Prostatic Biomarkers of Testosterone-Induced Benign Prostate Hyperplasia in Male Albino Rats

The study examined the effects of ethanol extract from the stem of Zapoteca portoricensis on testosterone-induced benign prostate hyperplasia (BPH) in 25 male albino rats. The extract was safe at 5000 mg/kg and significantly reduced liver enzymes (ALP, ALT, AST), serum total bilirubin, creatinine, and urea levels, indicating protective effects on liver and kidney function. It also decreased prostatic acid phosphatase and 5-alpha reductase activities, suggesting therapeutic benefits for BPH without harming liver or kidney integrity. The findings suggested the extract could alleviate or protect against BPH-induced damage in rats.