Evaluation of Methotrexate-Loaded Surfactants, Ceramides, and Cholesterol-Based Lamellar Phases as a Topical Treatment for Psoriasis

    February 2022 in “ Journal of Pharmacy and Pharmacology ”
    Cintia Oliveira Alves, Rômulo Dias Novaes, Maria Tereza Carneiro Paschoal Bernardes, Reggiani Vilela Gonçalves, Laíla Pereira da Silva, Sandra Barbosa Neder Agostini, Gislaine Ribeiro Pereira, Flávia Chiva Carvalho
    TLDR Methotrexate-loaded formulations showed promise for psoriasis treatment but need careful evaluation.
    The study evaluated methotrexate-loaded lamellar phases (C1CH and C1CHCE) as topical treatments for psoriasis in mice. These formulations, based on stearic acid, cholesterol, and ceramides, showed significant immunomodulatory effects and induced skin remodeling, increasing keratinization, epidermis thickness, and inflammatory infiltrate. They also affected various biomarkers, such as IL-1, IFN-γ, TNF-α, and prostaglandin E2. Despite the potential of liquid crystals for drug delivery, the study concluded that their use should be carefully assessed individually.
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