Evolutionary Divergence of Fibroblast Growth Factors Across Species: Insight Into Functional Diversification

The study investigates the evolutionary divergence of fibroblast growth factors (FGFs) across species, focusing on their role in skin biology. By analyzing 22 FGF genes in Mus musculus and comparing them with those in rodents, primates, and birds, researchers found that while the FGF gene family is highly conserved, there are instances of gene loss in birds. Significant differences in skin expression between rodents and primates suggest links to evolutionary and environmental adaptations. The study also highlights a potential synergistic role of FGFs and Epidermal Growth Factors (EGFs) in wound healing, with EGFs being crucial in early stages. This research provides insights into the genetic architecture and functional diversification of FGFs, offering a foundation for further studies on their role in skin functions.