Exosomes in Dermatology.

Exosomes are nanosized extracellular vesicles that play a significant role in dermatology by influencing keratinocyte and fibroblast proliferation, pigmentation pathways, and immune modulation in conditions like atopic dermatitis and cutaneous lupus. They are particularly effective in wound healing by reducing proinflammatory cytokines, enhancing angiogenesis, and improving collagen deposition and scar quality. Early studies indicate their potential in regenerative skin care, including reversing photoaging, improving skin elasticity, and stimulating hair follicle growth. Although currently used mainly in cosmetic applications without FDA approval, exosomes show promise for therapeutic use in chronic wounds, inflammatory dermatoses, and pigmentation disorders, highlighting the need for further research and regulatory guidance.