TLDR Extracellular vesicles help heal skin wounds and could be used for better treatments.
The review discussed the potential of extracellular vesicles (EVs) in enhancing skin wound healing across all four phases: hemostasis, inflammation, proliferation, and remodeling. EVs from sources like mesenchymal stem cells (MSCs) and plants were shown to promote cell proliferation, migration, and angiogenesis. MSC-derived EVs, particularly from umbilical cord, adipose tissue, and bone marrow, were effective in diabetic wound healing, influencing processes like coagulation and collagen synthesis through pathways such as PI3K/Akt and Wnt/β-catenin. Plant-derived EVs, though less studied, showed promise as cost-effective drug delivery systems with anti-oxidative and anti-inflammatory effects. The review highlighted the need for further research to fully understand EV mechanisms and suggested future development of smart hydrogels and multifunctional biomaterials to optimize EV delivery and wound healing outcomes.
19 citations
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June 2021 in “Tissue Engineering and Regenerative Medicine” Fat stem cell particles help regrow hair.
132 citations
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April 2021 in “Stem Cell Research & Therapy” A special membrane with cell particles helps heal diabetic wounds faster.
12 citations
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March 2021 in “Regenerative Engineering and Translational Medicine” Exosomes from stem cells might help treat hair loss.
139 citations
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May 2020 in “Stem Cell Research & Therapy” Exosomes from stem cells help wounds heal faster by affecting specific cell signals.
49 citations
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March 2019 in “Journal of Investigative Dermatology” Skin fat plays a key role in immune defense and healing beyond just storing energy.
1160 citations
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
132 citations
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January 2017 in “International Journal of Molecular Sciences” Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
40 citations
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January 2016 in “Elsevier eBooks” The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
854 citations
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February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.
