Familial Pure Hair–Nail Ectodermal Dysplasia In Yemen: A Father–Son Case Report With Clinical Correlation
January 2026
in “
Journal of Clinical and Investigative Dermatology
”
TLDR A father and son in Yemen have a genetic condition causing hair loss and nail problems.
The document discusses a case report of familial Pure Hair–Nail Ectodermal Dysplasia (PHNED) in Yemen, focusing on a father and son. PHNED, associated with the HOXC13 gene, often presents with severe hypotrichosis or complete alopecia. In this case, the father exhibited nail dystrophy affecting all 20 nails, characterized by distal dystrophy and marked downward curvature. This report highlights the clinical correlation of PHNED symptoms in a familial context.
