Host-Directed FDA-Approved Drugs With Antiviral Activity Against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods
November 2020
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
TLDR Five FDA-approved drugs may help block COVID-19 virus entry.
The study aimed to identify FDA-approved drugs with antiviral activity against SARS-CoV-2 by using a hierarchical in silico/in vitro screening method. This approach focused on host-based targets related to viral entry and involved both virtual and biological screening. As a result, five drugs—cepharantine, clofazimine, metergoline, imatinib, and efloxate—were identified as potentially repurposable for interfering with viral entry. The authors declared no competing interests.
