Iron-Curcumin-Carboxy PTIO Coordinated Nanoparticles With Anti-Inflammatory Properties for Enhanced Diabetic Wound Healing

The study developed iron-curcumin-coordinated nanoparticles (Fe-Cur-P) to improve curcumin's solubility and bioavailability for enhanced diabetic wound healing. These nanoparticles, with a size of 9.8 ± 0.6 nm and 21.31% drug loading, demonstrated pH-responsive release of carboxy-PTIO and potent antioxidant activity. In vitro, they reduced apoptosis and suppressed pro-inflammatory cytokines in LPS-stimulated macrophages. In vivo, Fe-Cur-P accelerated wound closure in diabetic mice, promoted vascularization and collagen deposition, and reduced inflammation, outperforming untreated controls and free curcumin. This suggests that Fe-Cur-P nanoparticles have significant therapeutic potential for treating diabetic wounds.