Fernblock Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM2.5-Induced Xenotoxic Stress

The study demonstrated that Fernblock®, a natural extract from Polypodium leucotomos, upregulated the NRF2 antioxidant pathway in human keratinocytes, providing protection against xenotoxic stress induced by PM2.5 pollutants and UVB radiation. The research involved 3 independent biological replicates and showed that Fernblock® increased the expression of antioxidant enzymes and detoxifying effectors, reduced UVB-induced inflammation and melanization, and enhanced autophagy, thereby promoting cell survival. The findings suggested that Fernblock® could serve as a protective agent against environmental stressors, potentially slowing skin aging by improving NRF2 signaling and reducing oxidative stress. The study was funded by Cantabria Labs and other Spanish institutions, with some authors affiliated with companies involved in Fernblock® production and distribution.