Induction of Ferroptosis by Natural Products in Non-Small Cell Lung Cancer: A Comprehensive Systematic Review

This comprehensive systematic review highlights the potential of natural products to induce ferroptosis as a novel therapeutic strategy for Non-Small Cell Lung Cancer (NSCLC). Ferroptosis, characterized by iron-dependent lipid peroxidation and accumulation of lipid reactive oxygen species, leads to cell death and presents a promising approach to overcoming NSCLC's challenges of tumor heterogeneity and drug resistance. The review emphasizes the potent activity and high safety profiles of natural compounds in targeting ferroptosis, although literature on this topic remains limited. The article aims to provide valuable insights into the mechanisms by which natural products can selectively induce ferroptosis and modulate NSCLC pathogenesis.