Induction of Ferroptosis by Natural Products in Non-Small Cell Lung Cancer: A Comprehensive Systematic Review

This comprehensive systematic review examines the potential of natural products to induce ferroptosis, a form of programmed cell death, as a therapeutic strategy for Non-Small Cell Lung Cancer (NSCLC). The review identifies several natural compounds, such as Timosaponin AIII, Curcumin, and Sanguinarine, which can modulate ferroptosis pathways by increasing iron accumulation, reactive oxygen species (ROS) production, and lipid peroxidation, while reducing glutathione (GSH) levels. These compounds target proteins and pathways like GPX4 and SLC7A11 to inhibit NSCLC cell proliferation and metastasis. Despite the promising potential of these natural products, the review emphasizes the need for further research to fully understand their interactions, pharmacokinetics, and potential adverse effects, as well as the necessity for more clinical trials to evaluate their safety and effectiveness.