Finasteride as a Positive Control in Reproduction Studies

    January 2012
    Ariadne Gutiérrez Martínez, Balia Pardo Acosta, Rafael Gámez Menéndez, Rosa Más Ferreiro, Haydeé García Cambián, Edy Goicochea Carrero
    TLDR Finasteride causes reproductive changes in male rats.
    The study investigated the effects of finasteride, a 5 α-reductase inhibitor, on the reproductive development of male rats when administered to pregnant Sprague Dawley rats during the sexual differentiation period. Finasteride was given orally at a dose of 10 mg/kg/day from gestation days 12 to 21. The results showed significant differences in the treated group compared to controls, including delayed testicular descent, delayed preputial separation, feminized traits such as nipple retention (100%), preputial cleft (83.9%), and reduced anogenital distance (90.3%). Additionally, 6.5% of the offspring had ectopic testes. The study confirmed that finasteride induced androgen-dependent developmental alterations and supported its use as a positive control in reproductive studies.
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